
Selective GH Secretagogue
MISSION CRITICAL: For in vitro laboratory research only. Not for human or veterinary use. Not evaluated by the FDA. Must be 21+.
Ipamorelin is a synthetic pentapeptide and selective growth hormone secretagogue. With the molecular formula C₃₈H₄₉N₉O₅ and a molecular weight of 711.9 g/mol (CAS: 170851-70-4), Ipamorelin is derived from the growth hormone-releasing peptide (GHRP) family and exhibits unique selectivity for growth hormone release.
Aib-His-D-2-Nal-D-Phe-Lys-NH2Ipamorelin selectively activates the ghrelin receptor (GHS-R1a) on somatotrophs, stimulating growth hormone release without significantly affecting other pituitary hormones (PMID: 10698741).
Receptor activation triggers phospholipase C-mediated signaling, increasing intracellular calcium and activating protein kinase C (PMID: 11916262).
Raun et al. (1998) characterized Ipamorelin's selective binding to GHS-R1a receptors and its effects on growth hormone release in pituitary cell cultures (PMID: 10698741).
Raun K, et al. (1998). Ipamorelin, a selective growth hormone secretagogue. Eur J Endocrinol.PMID: 11916262Johansen et al. (2002) investigated Ipamorelin's receptor binding kinetics and signaling pathways in CHO cells expressing GHS-R1a (PMID: 11916262).
Johansen PB, et al. (2002). Ipamorelin: pharmacological characterization in vitro. Growth Horm IGF Res.Scientific Context