
D-Amino Acid Retro-Inverso Peptide (Dri)
MISSION CRITICAL: For in vitro laboratory research only. Not for human or veterinary use. Not evaluated by the FDA. Must be 21+.
FOXO4-DRI is a D-amino acid retro-inverso peptide (DRI) and p53-interaction domain analog. With the molecular formula C₂₂₈H₃₉₀N₈₆O₇₅S₂ and a molecular weight of 5358.1 g/mol (CAS: 1449830-41-4), it structurally mimics endogenous peptides while extending its sequence.
D-amino acid sequence matching FOXO4-p53 binding domainPublished research demonstrates FOXO4-DRI modulates targeted signaling cascades within cell tissue models (PMID: 40593617).
In cellular environments, FOXO4-DRI exhibits selective binding and corresponding pathway activation (PMID: 34877934).
Bourgeois et al. (2025) investigated FOXO4-DRI's binding affinity and receptor interactions in vitro (PMID: 40593617).
Bourgeois B, et al. (2025). The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI. Nat Commun.PMID: 34877934Meng et al. (2021) investigated FOXO4-DRI's binding affinity and receptor interactions in vitro (PMID: 34877934).
Meng J, et al. (2021). Targeting senescence-like fibroblasts radiosensitizes non-small cell lung cancer and reduces radiation-induced pulmonary fibrosis. JCI Insight.Scientific Context