
Growth Hormone-Releasing Hormone Analog
MISSION CRITICAL: For in vitro laboratory research only. Not for human or veterinary use. Not evaluated by the FDA. Must be 21+.
CJC no DAC (CJC-1295 without Drug Affinity Complex) is a synthetic 29-amino acid growth hormone-releasing hormone analog with the molecular formula C₁₅₂H₂₅₂N₄₄O₄₂ and a molecular weight of 3367.9 g/mol (CAS: 446036-97-1). Unlike its DAC-conjugated counterpart, this variant lacks the drug affinity complex that extends plasma half-life, making it a research tool for studying pulsatile GHRH receptor signaling in endocrine cell models.
CJC no DAC binds the GHRH receptor and activates adenylyl cyclase, elevating intracellular cAMP in somatotroph cell models (PMID: 16352683).
Published studies demonstrate receptor-mediated GH secretion stimulation in anterior pituitary cell culture systems (PMID: 18458271).
Jetté et al. (2005) characterized GHRH analog receptor binding kinetics in anterior pituitary cell models (PMID: 16352683).
Jetté L, et al. (2005). hGRF1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary. J Pharm Sci.PMID: 18458271Ionescu et al. (2008) analyzed pulsatile GH secretion patterns following GHRH analog exposure in in vitro pituitary models (PMID: 18458271).
Ionescu M, et al. (2008). CJC-1295 effects on GH secretion. J Clin Endocrinol Metab.Scientific Context