What is TB500 used for?

TB500 is a synthetic peptide compound studied in laboratory research settings. Scientific literature has explored its properties in preclinical studies. It is not approved for human consumption.

What purity level does Onward Aminos's TB500 have?

Onward Aminos supplies TB500 at ≥99% purity, verified by third-party HPLC and mass spectrometry analysis. Certificates of Analysis are available upon request.

How is TB500 supplied?

TB500 is supplied as a lyophilized powder in sealed research-grade vials, intended for in vitro and laboratory research use only.

FREE SHIPPING THRESHOLD$250 REMAINING

SYSTEM: ACTIVE·INVENTORY // PEPTIDES·ITEM: TB500

MK-IV SPEC TB500

LAT: 34.0522° NLONG: 118.2437° W

RESEARCH ONLYOA-1113-TB5

TB500

Name: TB500
Brand: Onward Aminos
SKU: OA-TB500

Actin-Binding Peptide Fragment

UNIT COST$48.00

STATUSIN STOCK

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MISSION CRITICAL: For in vitro laboratory research only. Not for human or veterinary use. Not evaluated by the FDA. Must be 21+.

SPECIFICATIONS

CAS No.885340-08-9

Mol. Weight868.99 g/mol

Purity≥99.0% (HPLC)

FormLyophilized Powder

Storage−20°C · Lyophilized

Mol. FormulaC₃₈H₆₈N₁₀O₁₄

COMPOUND INTEL

REF #OA-1113-TB5

MECHANISM_DUMP

MOLECULAR PROFILE

TB-500 (Thymosin Beta-4 Fragment) is a synthetic 43-amino acid peptide representing the active region of the naturally occurring Thymosin Beta-4 protein. With the molecular formula C₂₁₂H₃₅₀N₅₆O₇₈S and a molecular weight of 4963.5 g/mol (CAS: 77591-33-4), TB-500 is the research designation for the peptide fragment containing the primary bioactive sequence of the parent protein.

AMINO ACID SEQUENCE

Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH

Actin-Binding Peptide FragmentActin CytoskeletonG-Actin Binding

MECHANISM OF ACTION

Actin CytoskeletonG-actin sequestration

TB-500 binds to monomeric G-actin, regulating actin polymerization and cytoskeletal dynamics in cell culture models (PMID: 15283699).

Cell MigrationIntegrin signaling

Published studies demonstrate effects on cell motility through interactions with integrin receptors and focal adhesion dynamics (PMID: 19189658).

TECHNICAL DATA

CAS No.: 885340-08-9
Mol. Formula: C₃₈H₆₈N₁₀O₁₄
Mol. Weight: 868.99 g/mol
Purity: ≥99.0% (HPLC)
Form: Lyophilized Powder
Storage: −20°C · Lyophilized

PMID REFERENCE LIBRARY

PMID: 15283699

Malinda et al. (2004) examined the actin-binding properties of thymosin beta-4 and its effects on keratinocyte migration in vitro (PMID: 15283699).

Malinda KM, et al. (2004). Thymosin beta4 accelerates wound healing. J Invest Dermatol.PMID: 19189658

Sosne et al. (2009) investigated TB-4 fragment's effects on corneal epithelial cell migration and integrin expression in cell culture models (PMID: 19189658).

Sosne G, et al. (2009). Thymosin beta4 promotes cell migration and wound healing. Exp Eye Res.PMID: 19549937

Huff et al. (2009) characterized the structure-function relationship of the actin-binding domain within thymosin beta-4 (PMID: 19549937).

Huff T, et al. (2009). Thymosin beta4: structure-function studies. FEBS J.