
Cytoprotective Peptide
MISSION CRITICAL: For in vitro laboratory research only. Not for human or veterinary use. Not evaluated by the FDA. Must be 21+.
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide derived from a partial sequence of human gastric juice protein. With the molecular formula C₆₂H₉₈N₁₆O₂₂ and a molecular weight of 1419.53 g/mol (CAS: 137525-51-0), BPC-157 consists of 15 amino acids. Published research has characterized its interactions with the nitric oxide system, GABAergic pathways, and dopaminergic systems in preclinical tissue models.
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-ValBPC-157 modulates nitric oxide synthase expression and activity, affecting vascular tone and tissue perfusion in preclinical models (PMID: 35489163).
Published research indicates interactions with vascular endothelial growth factor and fibroblast growth factor signaling cascades in tissue culture studies (PMID: 30915550).
BPC-157 has been shown to influence dopaminergic and GABAergic neurotransmission in neuronal cell culture models (PMID: 26809810).
Sikiric et al. (2022) investigated BPC-157's interactions with growth factor and cytokine signaling pathways in gastric tissue models (PMID: 35489163).
Sikiric P, et al. (2022). BPC-157 and its healing effects. Front Pharmacol.PMID: 30915550Seiwerth et al. (2019) examined BPC-157's molecular structure and receptor binding characteristics in endothelial cell cultures (PMID: 30915550).
Seiwerth S, et al. (2019). BPC 157: molecular mechanisms and therapeutic implications. Curr Pharm Des.PMID: 26809810Sikiric et al. (2016) characterized the amino acid sequence and cytoprotective mechanisms in epithelial cell models (PMID: 26809810).
Sikiric P, et al. (2016). Novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157. Regul Pept.PMID: 32786122Duzel et al. (2020) analyzed BPC-157's effects on fibroblast proliferation and extracellular matrix components in vitro (PMID: 32786122).
Duzel A, et al. (2020). BPC 157 and tissue repair mechanisms. Biomedicines.Scientific Context