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MK-IV SPEC
LAT: 34.0522° NLONG: 118.2437° W
RESEARCH ONLYOA-1021-IGF1LR
IGF-1LR3
Long Arginine
UNIT COST$62.00
STATUSIN STOCK
QTY
1
MISSION CRITICAL: For in vitro laboratory research only. Not for human or veterinary use. Not evaluated by the FDA. Must be 21+.
SPECIFICATIONS
CAS No.946870-92-4
Mol. Weight9117.5 g/mol
Purity≥99.0% (HPLC)
FormLyophilized Powder
Storage−20°C · Lyophilized
Mol. FormulaC400H625N111O115S9
COMPOUND INTEL
REF #OA-1021-IGF1LRMECHANISM_DUMP
MOLECULAR PROFILE
IGF-1 LR3 is a long arginine 3 IGF-1, a recombinant IGF-1 analog with an N-terminal extension and Arg3 substitution. With the molecular formula C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₆ and a molecular weight of 9111.6 g/mol (CAS: 143045-27-6), it structurally mimics endogenous peptides while extending its sequence.
AMINO ACID SEQUENCE
MFPAMPLSSLFVNGPRTLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGSTFEEHKLong ArginineIGF-1 ReceptorPI3K/AKT Signaling Pathway
MECHANISM OF ACTION
IGF-1 ReceptorReceptor interaction
Published research demonstrates IGF-1 LR3 modulates targeted signaling cascades within cell tissue models (PMID: 33938236).
PI3K/AKT Signaling PathwaySignaling cascade
In cellular environments, IGF-1 LR3 exhibits selective binding and corresponding pathway activation (PMID: 11469659).
TECHNICAL DATA
- CAS No.
- 946870-92-4
- Mol. Formula
- C400H625N111O115S9
- Mol. Weight
- 9117.5 g/mol
- Purity
- ≥99.0% (HPLC)
- Form
- Lyophilized Powder
- Storage
- −20°C · Lyophilized
PMID REFERENCE LIBRARY
PMID: 33938236
White et al. (2021) investigated IGF-1 LR3's binding affinity and receptor interactions in vitro (PMID: 33938236).
White A, et al. (2021). Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect. Am J Physiol Endocrinol Metab.PMID: 11469659Pesall et al. (2001) investigated IGF-1 LR3's binding affinity and receptor interactions in vitro (PMID: 11469659).
Pesall JE, et al. (2001). The effect of insulin-like growth factor analogs on turkey satellite cell and embryonic myoblast proliferation. Poult Sci.
