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MK-IV SPEC
LAT: 34.0522° NLONG: 118.2437° W
RESEARCH ONLYOA-963-GHKCU
GHK-Cu
Copper-Binding Tripeptide
UNIT COST$36.00
STATUSIN STOCK
SELECT MASS (MG)
QTY
1
MISSION CRITICAL: For in vitro laboratory research only. Not for human or veterinary use. Not evaluated by the FDA. Must be 21+.
SPECIFICATIONS
CAS No.49557-75-7
Mol. Weight340.38 g/mol (free tripeptide); ~403 g/mol (Cu complex)
Purity≥99.0% (HPLC)
FormLyophilized Powder
Storage−20°C · Lyophilized
Mol. FormulaC14H24N6O4 (free tripeptide)
COMPOUND INTEL
REF #OA-963-GHKCUMECHANISM_DUMP
MOLECULAR PROFILE
GHK-Cu (Copper Peptide Complex) is a tripeptide-copper complex consisting of glycine, histidine, and lysine bound to a copper ion. With the molecular formula C₁₄H₂₂CuN₆O₄ and a molecular weight of 404.8 g/mol (CAS: 49557-75-7), GHK-Cu is a naturally occurring copper carrier found in human plasma, saliva, and urine.
AMINO ACID SEQUENCE
Gly-His-LysCopper-Binding TripeptideTGF-beta PathwayIntegrin Receptors
MECHANISM OF ACTION
Copper TransportMetal ion chelation
GHK-Cu functions as a copper carrier, delivering copper ions to cells with high binding affinity and specificity (PMID: 25342275).
TGF-beta SignalingTGF-beta receptor modulation
Research indicates GHK-Cu influences transforming growth factor-beta signaling pathways in fibroblast cultures (PMID: 21982351).
Antioxidant ActivityROS scavenging
GHK-Cu exhibits copper-dependent superoxide dismutase-like activity in biochemical assays (PMID: 19098933).
TECHNICAL DATA
- CAS No.
- 49557-75-7
- Mol. Formula
- C14H24N6O4 (free tripeptide)
- Mol. Weight
- 340.38 g/mol (free tripeptide); ~403 g/mol (Cu complex)
- Purity
- ≥99.0% (HPLC)
- Form
- Lyophilized Powder
- Storage
- −20°C · Lyophilized
PMID REFERENCE LIBRARY
PMID: 25342275
Pickart et al. (2014) characterized GHK-Cu's copper-binding affinity and its effects on gene expression in fibroblast cultures (PMID: 25342275).
Pickart L, et al. (2014). GHK-copper peptide in skin remodeling and repair. Biol Chem.PMID: 21982351Pickart et al. (2011) investigated GHK-Cu's modulation of metalloproteinase and collagen gene expression in vitro (PMID: 21982351).
Pickart L, et al. (2011). GHK-Cu peptide affects gene expression in human keratinocytes. J Pept Sci.PMID: 19098933Pickart et al. (2008) reviewed GHK-Cu's copper transport mechanisms and antioxidant properties in cellular models (PMID: 19098933).
Pickart L, et al. (2008). The human tripeptide GHK-Cu in tissue repair. Int J Cosmet Sci.
