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MK-IV SPEC
LAT: 34.0522° NLONG: 118.2437° W
RESEARCH ONLYOA-973-GLP1
GLP-1
Endogenous Incretin Hormone
UNIT COST$103.00
STATUSIN STOCK
QTY
1
MISSION CRITICAL: For in vitro laboratory research only. Not for human or veterinary use. Not evaluated by the FDA. Must be 21+.
SPECIFICATIONS
CAS No.106612-94-6 (GLP-1 7-37)
Mol. Weight3337.73 g/mol
Purity≥99.0% (HPLC)
FormLyophilized Powder
Storage−20°C · Lyophilized
Mol. FormulaC151H226N40O46
COMPOUND INTEL
REF #OA-973-GLP1MECHANISM_DUMP
MOLECULAR PROFILE
GLP-1 (Semaglutide) is a synthetic analog of human glucagon-like peptide-1 (GLP-1) with 94% homology to native GLP-1. With the molecular formula C₁₈₇H₂₉₁N₄₅O₅₉ and a molecular weight of 4113.6 g/mol (CAS: 910463-68-2), it incorporates a C18 fatty di-acid side chain attached to lysine at position 26 and modified amino acid substitutions at positions 8 (Aib), 34 (Arg), and a truncated C-terminus.
AMINO ACID SEQUENCE
His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEA-AEEA-γ-Glu-eicosanedioic acid)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-GlyEndogenous Incretin HormoneGLP-1 ReceptorGs-protein coupled signaling
MECHANISM OF ACTION
GLP-1 ReceptorReceptor interaction
Published research demonstrates GLP-1 modulates targeted signaling cascades within cell tissue models (PMID: 41170292).
Gs-protein coupled signalingSignaling cascade
In cellular environments, GLP-1 exhibits selective binding and corresponding pathway activation (PMID: 41030574).
TECHNICAL DATA
- CAS No.
- 106612-94-6 (GLP-1 7-37)
- Mol. Formula
- C151H226N40O46
- Mol. Weight
- 3337.73 g/mol
- Purity
- ≥99.0% (HPLC)
- Form
- Lyophilized Powder
- Storage
- −20°C · Lyophilized
PMID REFERENCE LIBRARY
PMID: 41170292
Abulfaraj et al. (2025) investigated GLP-1's binding affinity and receptor interactions in vitro (PMID: 41170292).
Abulfaraj M, et al. (2025). Infected necrotizing pancreatitis: clinical features, microbial patterns, and outcomes in a Saudi tertiary center. Front Cell Infect Microbiol.PMID: 41030574Sun et al. (2025) investigated GLP-1's binding affinity and receptor interactions in vitro (PMID: 41030574).
Sun Y, et al. (2025). Exosomal miR-450b-5p Secreted from Exendin-4-Stimulated Endothelial Cells Protects Retinal Ganglion Cells Against Ischemia Reperfusion Injury. Int J Nanomedicine.
Scientific Context